Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias
نویسندگان
چکیده
منابع مشابه
Heterogeneity in the circumsporozoite protein gene of Plasmodium malariae isolates from sub-Saharan Africa.
Polymorphism of the circumsporozoite protein (CSP) of Plasmodium malariae was characterized by comparing gene sequences of twelve field isolates obtained in Yaoundé, Cameroon, Central Africa, and one clinical isolate originating from Côte d'Ivoire, West Africa. The length of the CSP gene ranged from 1266 to 1302 bp. The size polymorphism was due to variation in the number of tandem repeat units...
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We produced a hybridoma secreting an immunoglobulin G1 monoclonal antibody against the circumsporozoite protein of the human malaria parasite Plasmodium malariae (Uganda 1/CDC). The monoclonal antibody produces a circumsporozoite precipitation reaction when incubated with viable sporozoites of P. malariae and reacts at high titers with heat-fixed sporozoites in an indirect immunofluorescent ant...
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circumsporozoite protein (csp) is one of the stage specific antigens, which is used for the development of vaccines and to investigate the genetic diversity in plasmodium falciparum malaria parasite. polymerase chain reaction was used for typing of csp genes on 67 positive falciparum malaria patients from sistan and baluchistan province of iran. three fragments were detected for csp gene. twent...
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BACKGROUND The merozoite surface protein 1 (MSP1) gene encodes the major surface antigen of invasive forms of the Plasmodium erythrocytic stages and is considered a candidate vaccine antigen against malaria. Due to its polymorphisms, MSP1 is also useful for strain discrimination and consists of a good genetic marker. Sequence diversity in MSP1 has been analyzed in field isolates of three human ...
متن کاملMonoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein
Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2018
ISSN: 1475-2875
DOI: 10.1186/s12936-018-2413-3